Synthesis and analgesic activity of new phenoxybenzylidene aroylhydrazine derivatives
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Abstract:
A series of phenoxybenzylidene aroylhydrazine derivatives were synthesized and their structureswere confirmed using FT-IR and 1H-NMR spectroscopy. Analgesic profiles of all compoundswere examined using abdominal constriction test (writhing test). Most of synthesized compoundsinduced significant reduction in the writhing response as compared with controls. The mostactive compounds exhibited an analgesic activity comparable with that of mefenamic acid.
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Journal title
volume 2 issue 1
pages 57- 63
publication date 2013-12-01
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